Heidi-lynn Ploeg

Associate Professor

Room: 3043
Mechanical Engineering Building
1513 University Avenue
Madison, WI 53706

Ph: (608) 262-2690
Fax: (608) 265-2316
ploeg@engr.wisc.edu


Profile Summary

The research goal of my Bone and Joint Research Laboratory is to understand the human musculo-skeletal system better, in order to aid the development of biomechanical and safe solutions for the prevention, care and treatment of diseased or injured systems. My research applies both experimental and computational methods to investigate the human subject over a wide range of scales from musculoskeletal biomechanics down to bone microstructures. The creation of advanced prevention and treatment strategies requires an understanding of their effects on the tissue structures of the body. Biomechanical models that replicate the physical and physiological behavior of tissue structures are an enabling technology for assessing this interaction. The aim of my research is to evolve the sophistication of biomechanical models, in the form of physical surrogates and computer simulations, in order to refine novel prevention and treatment strategies. Multidisciplinary, industrial and clinical collaborations are required, and therefore, are a natural product of research in this field.

The combination of computational and experimental methods provides a powerful synergy towards the understanding of human biomechanics in the development of innovative strategies for the prevention and treatment of diseases of or injuries to the musculoskeletal system. In view of the time and resource requirements of running biomechanical experiments, there are several advantages to computational modeling of human bones and joints, including: repeatability, reproducibility, adaptability, accessibility and transferability. That is not to say computational modeling replaces experimental methods; but, they are powerful compliments. In vitro and in vivo experiments are required to generate and validate accurate computer models; and, computational models can be applied to design and analyze efficient experiments. The development of an accurate human joint model requires anthropometric and material data of the bone and surrounding tissues, definition of the boundary conditions, and validation. Using numerical algorithms of bone-remodeling, an accurate finite element model may also be used to predict bone adaptation due to changes in its loading environment, for example due to rehabilitation therapy or a surgical procedure.

Education

  • Queen\'s University, Kingston, Ontario, Canada:
  • B.Sc. Mech. Eng. 1988
  • M.Sc. Mech. Eng. 1991
  • Ph.D. Mech. Eng. 2000

Research Interests

  • bone modelling and remodelling
  • orthopaedic implant design and analysis
  • biomechanics of joints
  • finite element analysis
  • fatigue of materials

Awards, Honors and Societies

  • Best Paper Award at NAFEMS World Congress 2001
  • New Investigator Recognition Award at Combined ORS 2001
  • Member, International Society of Biomechanics
  • Member, Canadian Society of Biomechanics
  • Member, American Society of Mechanical Engineers
  • Member, American Society of Biomechanics
  • Member, European Society of Biomechanics
  • Member, American Society of Testing and Materials

Publications

  1. Slane J., Vivanco J., Meyer J., Ploeg H.L., Squire M., Modification of acrylic bone cement with mesoporous silica nanoparticles: effects on mechanical, fatigue and absorption properties, Journal of the Mechanical Behavior of Biomedical Materials 29(January):451-461, 2014. DOI:http://dx.doi.org/10.1016/j.jmbbm.2013.10.008.
  2. Crookshank M.C., Ploeg H., Ellis R., MacIntyre N.J., Repeatable calibration of Hounsfield units to mineral density and effect of scanning medium, Advances in Biomechanics and Applications 1(1):15-22, 2013. DOI:http://dx.doi.org/10.12989/aba.2013.1.1.015
  3. Riehl J., Soukup J.W., Collins C., Siverling S., Ploeg H., Snyder C. J., Effect of preparation surface area on the clinical outcome of full veneer crowns in dogs, Journal of Veterinary Dentistry, accepted Nov. 2012.
  4. Burgers T. A., Hoffmann M. F., Collins C. J., Zahatnansky J., Alvarado M. A., Morris M. R., Sietsema D. L., Mason J. J., Jones C. B., Ploeg H., Williams B. O., Mice Lacking Pten in Osteoblasts Have Improved Intramembranous and Late Endochondral Fracture Healing, PloS one 8(5):e63857, 2013. PMID: 23675511
  5. Kersh M. E., Ploeg H., Pandy M. G., The dependence of knee joint stability on the cruciate and collateral ligaments, Movement & Sport Sciences-Science & Motricité, online 22 May, 2013. http://dx.doi.org/10.1051/sm/2013049
  6. Vivanco J., Garcia S., Ploeg H., Alvarez G., Cullen D., Smith E.L. Apparent elastic modulus of ex vivo trabecular bovine bone increases with dynamic loading, Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine 227(8):902-910, 2013. PMID:23674578
  7. Vivanco J., Araneda A., Ploeg H.L., Effect of Sintering Temperature on Microstructural Properties of Bioceramic Bone Scaffolds, in Biomaterials Science: Processing, Properties and Applications II: Ceramic Transactions, Volume 237, 2012 (eds R. Narayan, S. Bose and A. Bandyopadhyay), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118511466.ch11
  8. Weisse B., Aiyangar A., Affolter Ch., Gander R., Terrasi G. P., Ploeg H., Determination of the translational and rotational stiffnesses of a L4-L5 functional spinal unit using a specimen-specific finite element model, Journal of the Mechanical Behavior of Biomedical Materials, 13:45-61, 2012. http://dx.doi.org/10.1016/j.jmbbm.2012.04.002
  9. Vivanco J., Aiyangar A., Araneda A., Ploeg H., Mechanical characterization of injection molded macro porous bioceramic bone scaffolds, Journal of Mechanical Behavior of Biomedical Materials, Journal of Mechanical Behavior of Biomedical Materials, 9:137-52, 2012. PMID 22498292
  10. Aiyangar A.K., Au A.G., Anderson A.P., Ploeg H., Comparison of two bone surrogates for interbody device subsidence testing, Journal of ASTM International, 9(1), 2012. ISSN1546-962X.
  11. Vivanco J., Slane J., Nay R., Simpson A., Ploeg H.L., The effect of sintering temperature on the microstructure and mechanical properties of a bioceramic bone scaffold, Journal of Mechanical Behavior of Biomedical Materials, 4(8):2150-60, 2011. PMID: 22098915
  12. Au A.G., Aiyangar A.K., Anderson A.P., Ploeg H., Replicating interbody device subsidence with lumbar vertebrae surrogates, Proceedings of the Institution of Mechanical Engineering-Part H: Journal of Engineering in Medicine, 225:972-985, 2011. PMID 22204119
  13. Slane J., Timmerman M., Ploeg H., Thelen D., The influence of glove and hand position on pressure over the ulnar nerve during cycling, Clinical Biomechanics, 26(6):642-8, 2011. PMID: 21458120
  14. Levasseur A., Ploeg H., Petit Y., Comparison of influences of structural characteristics on bulk mechanical behaviour of bone: experimental study using a bone surrogate, Medical and Biological Engineering and Computing, 50(1):61-7, 2011. PMID 21431937
  15. Au A.G., Aiyangar A.K., Anderson A.P., Ploeg H., A new surrogate bone model for testing interbody device subsidence, Spine, 36(16):1289-96, 2011. PMID: 21311401
  16. Vivanco J., Smith B., Blake A., Williams J., Turner K., Ploeg H., 3D Elastomeric scaffolds fabricated by casting in micro end milled molds, Journal of Biomimetics, Biomaterials and Tissue Engineering 9:17-23, 2011. DOI: 10.4028/www.scientific.net/JBBTE.9.17
  17. Aiyangar A.K., Crenshaw T.D., Au A.G., Ploeg H., Recovery of bone strength in young pigs from an induced short-term dietary calcium deficit followed by a calcium replete diet, Medical Engineering & Physics 32(10):1116-1123, 2010. PMID: 20920874
  18. Burgers T.A., Mason J., Squire M.W., Ploeg H., Time dependent fixation and implant forces for a femoral knee component: an in vitro study, Medical Engineering & Physics, 32(9):968-973, 2010. PMID: 20674458
  19. Burgers T., Lakes R., Ploeg H., Post yield relaxation behavior of bovine cancellous bone, Journal of Biomechanics, 42(16):2728-2733, 2009. PMID: 19765712
  20. Kersh M.E. and Ploeg H., A methodology for the pre-clinical evaluation of patellar implants, International Journal of Experimental and Computational Biomechanics, 1(2):129-145, 2009. DOI: 10.1504/IJECB.2009.029189
  21. Vivanco J., Fang S., Levine D., Ploeg H., Evaluation of the mechanical behavior of direct compression molded porous tantalum-UHMWPE construct: a microstructural model, Journal of Applied Biomaterials and Biomechanics, 7(1):1-9, 2009. PMID: 20740437
  22. Ploeg H., Buergi M., Wyss U., Hip stem fatigue test prediction, International Journal of Fatigue 31(5):894-905, 2009. DOI: 10.1016/j.ijfatigue.2008.10.005
  23. Burgers T., Mason J., Ploeg H., Initial Fixation of a Femoral Knee Component: An In Vitro and Finite Element Study, International Journal of Experimental and Computational Biomechanics, 1(1):23-44, 2009. DOI: 10.1504/IJECB.2009.022857
  24. Schmidt J., Berg D., Ploeg E.L., Ploeg H., Precision, repeatability and accuracy of Optotrak® active-marker motion tracking system, International Journal of Experimental and Computational Biomechanics, 1(1):113-127, 2009. DOI: 10.1504/IJECB.2009.022862
  25. Potter J., Sauer J., Weisshaar C., Thelen D., Ploeg H., Gender differences in bicycle saddle pressure distribution during seated cycling, Journal of Medicine & Science in Sports & Exercise, 40(6):1126-1134, June 2008. PMID: 18460992
  26. García S., Smith E., Ploeg H., A calibration procedure for a bone loading system, Journal of Medical Devices, 2:0106-1-01106-6, March 2008. DOI: 10.1115/1.2889059
  27. Burgers T., Mason J., Niebur G., Ploeg H., Compressive properties of trabecular bone in the distal femur, Journal of Biomechanics, 41:1077-1085, 2008. PMID: 18206893
  28. Sauer, J.L., Potter, J.J., Weisshaar, C.L., Ploeg, H., Thelen, D.G., Influence of gender, power and hand position on pelvic motion during seated cycling, Medicine & Science in Sports & Exercise, 39:2204-2211, 2007. PMID: 18046192
  29. Schmitz M.J., Clift S.E., Taylor W.R., Hertig D., Warner M.D., Ploeg H., Bereiter H., Investigating the effect of mechanotransductive signal type on the finite element based prediction of bone remodelling around the Thrust Plate Prosthesis: A patient specific comparison, Proc Inst Mech Eng [H] 218(6):417-424, 2004. PMID: 15648665
  30. Taylor W.R., Ploeg H., Hertig D., Warner M.D., Clift S.E., Bone remodelling of a proximal femur with the Thrust Plate Prosthesis: An in-vitro case, Computer Methods in Biomechanics and Biomedical Engineering 7(3):131-137, 2004. PMID: 15512756
  31. Herren D.B., Ploeg H., Hertig D., Klabunde R., Modeling and finite element analysis of a new revision implant for the elbow, Clinical Orthopaedics and Related Research 420:292-297, March 2004. PMID: 15057111
  32. Taylor W.R., Roland E., Rakotomanana L., Ploeg H., Hertig D., Klabunde R., Warner M.D., Clift S.E., A method for determining orthotropic materials properties for a long bone from CT data using FE modal analysis, Journal of Biomechanics 35:767-773, 2002. PMID: 12020996
  33. Ploeg H.L., Wevers H.W., Wyss U.P., Bürgi M., Fatigue strength testing of hip stems with statistical analysis, Bio-Medical Materials and Engineering 9(4):243-263, 1999. PMID: 10674178
  34. Frei S., Ploeg H., Reinschmidt C., Heuberger P. Fracturas de implantes de tibia - Consecuencias para las pruebas de los implantes (Tibial implant fractures – Consequences for implant testing), Biomecanica VII 13:58-64, 1999. http://hdl.handle.net/2099/5502

Links

Classes

InterEgr102 Introduction to Society\'s Engineering Grand Challenges

InterEgr160 Introduction to Engineering Design

ME306 Mechanics of Materials

ME342 Design of Machine Elements

ME351 and ME352 Interdisciplinary Experiential Design Projects I and II

ME603 Orthopaedic Biomechanics, Design of Orthopaedic Implants

Courses

Summer 2014

  • ME 492 - Mechanical Engineering Projects II

  • ME 491 - Mechanical Engineering Projects I
  • ME 890 - PhD Research and Thesis
  • ME 790 - Master\'s Research and Thesis
  • ME 291 - Ungergraduate Mechanical Engineering Projects
  • ME 699 - Advanced Independent Study
  • ME 352 - Interdisciplinary Experiential Design Projects II
  • ME 351 - Interdisciplinary Experiential Design Projects I
  • ME 489 - Honors in Research
  • ME 990 - Dissertator Research and Thesis
  • BME 790 - Master\'s Research and Thesis
  • BME 699 - Advanced Independent Study
  • BME 399 - Independent Study
  • INTEREGR 102 - Introduction to Society\'s Engineering Grand Challenges
  • ME 492 - Mechanical Engineering Projects II
  • ME 491 - Mechanical Engineering Projects I
  • ME 790 - Master\'s Research and Thesis
  • ME 291 - Ungergraduate Mechanical Engineering Projects
  • ME 699 - Advanced Independent Study
  • ME 352 - Interdisciplinary Experiential Design Projects II
  • ME 351 - Interdisciplinary Experiential Design Projects I
  • ME 489 - Honors in Research
  • ME 990 - Dissertator Research and Thesis
  • ME 890 - PhD Research and Thesis
  • BME 890 - Pre-dissertation Research
  • BME 790 - Master\'s Research and Thesis
  • BME 699 - Advanced Independent Study
  • BME 399 - Independent Study
  • ME 790 - Master\'s Research and Thesis
  • ME 699 - Advanced Independent Study
  • ME 489 - Honors in Research
  • ME 990 - Dissertator Research and Thesis
  • ME 890 - PhD Research and Thesis
  • BME 890 - Pre-dissertation Research
  • BME 790 - Master\'s Research and Thesis
  • BME 399 - Independent Study
  • Secondary Contact

    Office:
    3034 Mechanical Engineering
    1513 University Avenue
    Madison, WI 53706

    Profile Summary

    The research goal of my Bone and Joint Research Laboratory is to understand the human musculo-skeletal system better, in order to aid the development of biomechanical and safe solutions for the prevention, care and treatment of diseased or injured systems. My research applies both experimental and computational methods to investigate the human subject over a wide range of scales from musculoskeletal biomechanics down to bone microstructures. The creation of advanced prevention and treatment strategies requires an understanding of their effects on the tissue structures of the body. Biomechanical models that replicate the physical and physiological behavior of tissue structures are an enabling technology for assessing this interaction. The aim of my research is to evolve the sophistication of biomechanical models, in the form of physical surrogates and computer simulations, in order to refine novel prevention and treatment strategies. Multidisciplinary, industrial and clinical collaborations are required, and therefore, are a natural product of research in this field.

    The combination of computational and experimental methods provides a powerful synergy towards the understanding of human biomechanics in the development of innovative strategies for the prevention and treatment of diseases of or injuries to the musculoskeletal system. In view of the time and resource requirements of running biomechanical experiments, there are several advantages to computational modeling of human bones and joints, including: repeatability, reproducibility, adaptability, accessibility and transferability. That is not to say computational modeling replaces experimental methods; but, they are powerful compliments. In vitro and in vivo experiments are required to generate and validate accurate computer models; and, computational models can be applied to design and analyze efficient experiments. The development of an accurate human joint model requires anthropometric and material data of the bone and surrounding tissues, definition of the boundary conditions, and validation. Using numerical algorithms of bone-remodeling, an accurate finite element model may also be used to predict bone adaptation due to changes in its loading environment, for example due to rehabilitation therapy or a surgical procedure.


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