Dr. Safdar's research focuses on healthcare-associated infections particularly in the acute care setting. She is interested in examining the efficacy of novel interventions to reduce healthcare-associated infection such as the use of probiotics for reducing colonization by methicillin-resistant Staphylococcus aureus and Clostridium difficile and has ongoing trials in this area. She has received research funding through the Department of Veterans Affairs, the University of Wisconsin Partnership for the Future Program, the Wisconsin Womens Health Foundation, the John A Hartford Foundation, and as a scholar from the National Institute on Aging {K-12- PI: Carnes}.