Michael Murrell

Assistant Professor

Engineering Centers Building
1550 Engineering Drive
Madison, WI 53706

mmurrell2@wisc.edu

Primary Affiliation:
Biomedical Engineering

Additional Affiliations:
Materials Science and Engineering,


Profile Summary

My interests are in understanding the mechanical principles that drive major cellular life processes through the design and engineering of novel biomimetic systems.  To this end, I develop simplified and tractable experimental models of the mechanical machinery within the cell with the goal of reproducing complex cellular behavior, such as cell division and cell migration.  I then combine these ‘bottom-up’ experimental models with concepts from soft matter physics to gain a fundamental understanding of the influence of mechanics on cell and tissue behavior.  In parallel, I hope to identify new design principles from biology which can be used to create novel technologies.  

Education

  • Postdoctoral Fellow, 2009-2013, University of Chicago
  • Visiting Scholar, 2009-2013, Institut Curie (France)
  • PhD 2009, MIT
  • BS 2004, Johns Hopkins University

Research Interests

  • Molecular, Cellular, and Tissue Biomechanics
  • Systems Biology
  • Cellular Engineering
  • Cell Motility and Tissue Dynamics

Publications

  • M. Murrell, M. Gardel, F-actin Buckling Coordinates Contractility and Severing in a Biomimetic Actomyosin Cortex, PNAS, Vol 109, no. 51, 2012
  • M. Murrell*, L.L. Pontani*, K. Guevorkian, D. Cuvelier , P. Nassoy and C. Sykes (2011), Spreading Dynamics of Biomimetic Actin Cortices, Biophysical Journal,  Vol 100, Issue 6, pp 1400-1409
  • M. Murrell, RD. Kamm, and PT. Matsudaira (2011), Tension, Cell Damage, and Free Space in a Microfluidic Wound Healing Assay, PLoS ONE 6(9):e24283. doi:10.1371/journal.pone.0024283
  • M. Murrell, R.D. Kamm and P.T. Matsudaira (2011), Substrate Viscosity Enhances Correlation in Epithelial Cell Motion, Biophysical Journal, Vol 101, Issue 2, pp 297-306
  • M. Socolovsky*, M. Murrell*,  Y. Liu,  R. Pop,  E. Porpiglia, A. Levchenko (2007), Negative Autoregulation by FAS mediates robust erythropoiesis, PLOS Biology,  Vol 5, Issue 10, pp  2297-2311
  • M. Murrell, K.J. Yarema, A.L. Levchenko (2005), Computational Modeling in Glycosylation, Handbook of Carbohydrate Engineering, Taylor and Francis
  • M. Murrell, K.J. Yarema, A.L. Levchenko (2004), The Systems Biology of Glycosylation, ChemBioChem, Vol 5, Issue 10, pp 1334 - 1347

Links

Accomplishments

  • 2010-2012 Postdoctoral Fellowship, Institute For Complex Adaptive Matter
  • 2005-2008 NIH Biotechnology Training Grant
  • 2004 MIT Presidential Fellow

Courses

Fall 2014-2015

  • BME 890 - Pre-dissertation Research
  • BME 399 - Independent Study
  • BME 890 - Pre-dissertation Research
  • BME 601 - Special Topics in Biomedical Engineering
  • BME 399 - Independent Study
  • MS&E 699 - Independent Study
  • MS&E 401 - Special Topics in Materials Science and Engineering
  • Profile Summary

    My interests are in understanding the mechanical principles that drive major cellular life processes through the design and engineering of novel biomimetic systems.  To this end, I develop simplified and tractable experimental models of the mechanical machinery within the cell with the goal of reproducing complex cellular behavior, such as cell division and cell migration.  I then combine these ‘bottom-up’ experimental models with concepts from soft matter physics to gain a fundamental understanding of the influence of mechanics on cell and tissue behavior.  In parallel, I hope to identify new design principles from biology which can be used to create novel technologies.  


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