Michael Murrell

Assistant Professor

Engineering Centers Building
1550 Engineering Drive
Madison, WI 53706

mmurrell2@wisc.edu


Profile Summary

My interests are in understanding the mechanical principles that drive major cellular life processes through the design and engineering of novel biomimetic systems.  To this end, I develop simplified and tractable experimental models of the mechanical machinery within the cell with the goal of reproducing complex cellular behavior, such as cell division and cell migration.  I then combine these ‘bottom-up’ experimental models with concepts from soft matter physics to gain a fundamental understanding of the influence of mechanics on cell and tissue behavior.  In parallel, I hope to identify new design principles from biology which can be used to create novel technologies.  

Education

  • Postdoctoral Fellow, 2009-2013, University of Chicago
  • Visiting Scholar, 2009-2013, Institut Curie (France)
  • PhD 2009, MIT
  • BS 2004, Johns Hopkins University

Research Interests

  • Molecular, Cellular, and Tissue Biomechanics
  • Systems Biology
  • Cellular Engineering
  • Cell Motility and Tissue Dynamics

Publications

  • M. Murrell, M. Gardel, F-actin Buckling Coordinates Contractility and Severing in a Biomimetic Actomyosin Cortex, PNAS, Vol 109, no. 51, 2012
  • M. Murrell*, L.L. Pontani*, K. Guevorkian, D. Cuvelier , P. Nassoy and C. Sykes (2011), Spreading Dynamics of Biomimetic Actin Cortices, Biophysical Journal,  Vol 100, Issue 6, pp 1400-1409
  • M. Murrell, RD. Kamm, and PT. Matsudaira (2011), Tension, Cell Damage, and Free Space in a Microfluidic Wound Healing Assay, PLoS ONE 6(9):e24283. doi:10.1371/journal.pone.0024283
  • M. Murrell, R.D. Kamm and P.T. Matsudaira (2011), Substrate Viscosity Enhances Correlation in Epithelial Cell Motion, Biophysical Journal, Vol 101, Issue 2, pp 297-306
  • M. Socolovsky*, M. Murrell*,  Y. Liu,  R. Pop,  E. Porpiglia, A. Levchenko (2007), Negative Autoregulation by FAS mediates robust erythropoiesis, PLOS Biology,  Vol 5, Issue 10, pp  2297-2311
  • M. Murrell, K.J. Yarema, A.L. Levchenko (2005), Computational Modeling in Glycosylation, Handbook of Carbohydrate Engineering, Taylor and Francis
  • M. Murrell, K.J. Yarema, A.L. Levchenko (2004), The Systems Biology of Glycosylation, ChemBioChem, Vol 5, Issue 10, pp 1334 - 1347

Links

Accomplishments

  • 2010-2012 Postdoctoral Fellowship, Institute For Complex Adaptive Matter
  • 2005-2008 NIH Biotechnology Training Grant
  • 2004 MIT Presidential Fellow

Courses

Fall 2015-2016

  • BME 890 - Pre-dissertation Research
  • BME 399 - Independent Study
  • Profile Summary

    My interests are in understanding the mechanical principles that drive major cellular life processes through the design and engineering of novel biomimetic systems.  To this end, I develop simplified and tractable experimental models of the mechanical machinery within the cell with the goal of reproducing complex cellular behavior, such as cell division and cell migration.  I then combine these ‘bottom-up’ experimental models with concepts from soft matter physics to gain a fundamental understanding of the influence of mechanics on cell and tissue behavior.  In parallel, I hope to identify new design principles from biology which can be used to create novel technologies.  


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