Profile Summary

Development of optical techniques and instruments enable quantitative measurement of cells and tissue at length scales ranging from nanometers to centimeters. For many applications, optical methods provide unique advantages for minimizing cost and complexity of sample preparation, making these methods suitable for clinical and in vivo use.

Applications include cancer risk screening by detecting field carcinogenesis using Enhanced Backscattering Spectroscopy, quantification of nanoscale ultrastructural changes within cells using spectral microscopy, and investigation of eye disease using endogenous fluorescence spectroscopy.