Krishanu Saha

Assistant Professor

Room: 2142
Engineering Centers Building
1550 Engineering Drive
Madison, WI 53706

Ph: (608) 890-3423
ksaha@wisc.edu

Primary Affiliation:
Biomedical Engineering


Profile Summary

My interests lie in using human stem cells together with emerging engineering methods in material science and synthetic biology to make smarter therapeutics, model human disease, and advance personalized medicine.

Education

  • Postdoctoral Fellow 2007-2012, Whitehead Institute-MIT/Harvard University
  • PhD 2007, University of California-Berkeley
  • MPhil 2002, University of Cambridge (U.K.)
  • BS 2001, Cornell University

Research Interests

  • Personalized and Regenerative Medicine
  • Biomaterials Engineering
  • Stem Cell Biology
  • Developmental Biology
  • Signal transduction
  • Systems biology
  • Synthetic biology
  • Evolution & optimization of signaling proteins and networks
  • Design principles of spatial and temporal control networks in cells

Awards, Honors and Societies

  • 2009-2014, Society in Science: Branco Weiss Fellow
  • 2012, Sage Bionetworks Young Investigator Award
  • 2009, Ruth L. Kirschstein Individual Postdoctoral National Research Service (F32) Award (declined)
  • 2001-2005, National Science Foundation Graduate Research Fellow (deferred for 2002-05)
  • 2001-2002, Winston Churchill Scholar
  • 2001, J. William Fulbright Graduate Student Award for United Kingdom (declined)
  • 2000, Barry F. Goldwater Scholar

Publications

  • Saha K.*, Mei Y.*, Reisterer C.M., Pyzocha N., Yang J., Muffat J., Mitalipova M., Alexander M.R., Langer R., Anderson D.G. and Jaenisch R. (2011) &ldquo

  • Surface engineered substrates for improved human pluripotent stem cell culture under fully defined conditions.&rdquo
  • Proceedings of the National Academy of Sciences of the USA. 108(46), 18714-9. [*equal contribution]

    Saha K. and Hurlbut J.B. (2011) &ldquo

  • Treat donors as partners in biobank research.&rdquo
  • Nature. 478, 312-313.

    Mathews D.J.H., Graff G.D., Saha K., and Winickoff D.E. (2011) &ldquo

  • Access To Stem Cells And Data: Persons, Property Rights, And Scientific Progress.&rdquo
  • Science. 331, 725-727.

    Mei Y.*, Saha K.*, Bogatyrev S.R., Yang J., Hook A.L., Kalcioglu Z.I., Cho S.W., Mitalipova M., Pyzocha N., Rojas F., van Vliet K.J., Davies M.C., Alexander M.R., Langer R., Jaenisch R., and Anderson D.G. (2010) &ldquo

  • Combinatorial Development of Biomaterials for Clonal Growth of Human Pluripotent Stem Cells.&rdquo
  • Nature Materials. 9, 768-778. [*equal contribution]

    Hanna J., Saha K., and Jaenisch R. (2010) &ldquo

  • Pluripotency and Cellular Reprogramming: Facts, Hypotheses, Unresolved Issues.&rdquo
  • Cell. 143, 508-525.

    Saha K., Kim J., Irwin E., Yoon J., Momin F., Trujillo V., Schaffer D.V., Healy K.E., and R.C. Hayward (2010) &ldquo

  • Surface creasing instability of soft polyacrylamide cell culture substrates.&rdquo
  • Biophysical Journal. 99(12) L94-L96.

    Hanna J.*, Saha K.*, Pando B., van Zon J., Lengner C.J., Creyghton M.P., van Oudenaarden A., and Jaenisch R. (2009) &ldquo

  • Direct cell reprogramming is a stochastic process amenable to acceleration.&rdquo
  • Nature. 462, 595-601. [*equal contribution]

    Saha K. and R. Jaenisch (2009) &ldquo

  • Technical challenges in using human induced pluripotent stem cells to model disease.&rdquo
  • Cell Stem Cell. 5, 584-595.

    Carey B.W., Markoulaki S., Hanna J., Saha K., Gao Q., Mitalipova M., and Jaenisch R. (2009) &ldquo

  • Reprogramming of murine and human somatic cells using a single polycistronic vector.&rdquo
  • Proceedings of the National Academy of Sciences of the USA. 106(1), 157-162.

    Winickoff D.W.*, Saha K.*, and Graff G.* (2009) &ldquo

  • Opening Life Sciences Research and Development: Integrative Management of Data, IP and Ethics in Stem Cells&rdquo
  • Yale Journal of Health Policy, Law and Ethics. 9(1), 52-127. [*equal contribution]

    Saha K., Keung A., Irwin E.F., Li Y., Schaffer D.V. and Healy K.E. (2008) &ldquo

  • Substrate modulus directs neural stem cell behavior.&rdquo
  • Biophysical Journal. 95(9), 4426-4438.

    Wall S.T., Saha K., Ashton R.S., Kam K.R., Schaffer D.V. and Healy K.E. (2008) &ldquo

  • Multivalency of Sonic hedgehog conjugated to linear polymer chains modulates protein potency.&rdquo
  • Bioconjugate Chemistry. 19(4), 806-812.

    Saha K.*, Pollock J.F.*, Schaffer D.V., and Healy K.E. (2007) &ldquo

  • Designing synthetic materials to control stem cell phenotype.&rdquo
  • Current Opinion in Chemical Biology. 11(4), 381-7. [*equal contribution]

    Saha K., Irwin E.F., Kozhukh J., Healy K.E., and Schaffer D.V. (2007) &ldquo

  • Biomimetic interfacial interpenetrating polymer networks control neural stem cell behavior.&rdquo
  • Journal of Biomedical Materials Research: Part A. 81A:1.

    Saha K. and D.V. Schaffer (2006) &ldquo

  • Signaling dynamics in Sonic hedgehog tissue patterning.&rdquo
  • Development. 133, 889-900.

    Saha K., Bender F., Rasmusson A., and Gizeli E. (2003) \"Probing the viscoelasticity of protein layers with acoustic waveguide devices.\" Langmuir. 19(4), 1304-1311.

    Saha K., Bender F., and Gizeli E. (2003) \"Comparative study of IgG binding to bacterial proteins G and A: Non-equilibrium kinetic binding constant determination with the acoustic waveguide device.\" Analytical Chemistry. 75(4), 835-842.

     

Courses

Fall 2014-2015

  • BME 699 - Advanced Independent Study

  • BME 399 - Independent Study
  • BME 890 - Pre-dissertation Research
  • BME 790 - Master\'s Research and Thesis
  • Secondary Contact

    4168
    Wisconsin Institute for Discovery
    330 North Orchard Street
    Madison, WI 53715

    Profile Summary

    My interests lie in using human stem cells together with emerging engineering methods in material science and synthetic biology to make smarter therapeutics, model human disease, and advance personalized medicine.


    Update Profile