William Murphy

Harvey D. Spangler Professor

5405 Wisconsin Institute for Medical Research
1111 Highland Avenue
Madison, WI 53705

Ph: (608) 265-9978


  • BS 1998, Illinois Wesleyan University
  • MS2000, University of Michigan-Ann Arbor
  • PhD2002, University of Michigan-Ann Arbor
  • Postdoctoral Fellow 2002-2004, University of Chicago


  • BS 1998, Illinois Wesleyan University
  • MS2000, University of Michigan-Ann Arbor
  • PhD2002, University of Michigan-Ann Arbor
  • Postdoctoral Fellow 2002-2004, University of Chicago

Research Interests

  • Creation of new biomaterials using bioinspired approaches
  • Using biomaterials to define the stem cell microenvironment
  • Development of biomaterials for tissue regeneration (tissue engineering)
  • New approaches for drug delivery and gene therapy

Awards, Honors and Societies

  • Member: American Chemical Society Society for Biomaterials Biomedical Engineering Society Materials Research Society
  • Editorial Boards: Advanced Functional Materials, Acta Biomaterialia, NanoLIFE, Biomatter
  • 2010Vilas Associates Award
  • 2008NSF CAREER award
  • 2005IADR/AADR William J. Gies Award
  • 2003NIH National Research Service Award


  • W.J. King, N.J. Pytel, K. Ng, W.L. Murphy. Triggered drug release from dynamic microspheres via a protein conformational change. Macromolecular Bioscience, In Press, 2009.
  • W.J. King, L. Jongpaiboonkit, W.L. Murphy. Influence of FGF2 and PEG hydrogel matrix properties on hMSC viability and spreading, Journal of Biomedical Materials Research A, In press.
  • J.S. Lee, J.S. Lee, W.L. Murphy. Modular peptides promote human mesenchymal stem cell differentiation on biomaterial surfaces, Acta Biomaterialia, 2010
  • 6: 21-28.
  • Y. Lu, M.D. Markel, B. Nemke, J.S. Lee, B.K. Graf, W.L. Murphy. Influence of hydroxyapatite-coated and growth factor-releasing interference screws on tendon-bone healing in an ovine model, Arthroscopy, 2009
  • 20: 1427-34.
  • J.T. Koepsel, W.L. Murphy. Patterning discrete stem cell culture environments via localized SAM replacement, Langmuir, 2009
  • 25: 12825-34.
  • L. Jongpaiboonkit, T. Franklin-Ford, W.L. Murphy. Fabrication and characterization of mineral-coated poly(lactide-co-glycolide) microspheres, ACS Applied Materials and Interfaces, 2009
  • 1: 1504-1511.
  • J.S. Lee, J.S. Lee, A. Wagoner-Johnson, W.L. Murphy. Modular peptide growth factors for substrate-mediated stem cell differentiation, Angewandte Chemie Int. Ed., 2009
  • 48: 6266-6270.
  • K.J. Regehr, M. Domenech, J.T. Koepsel, K.C. Carver, S.J. Ellison-Zelski, W.L. Murphy, L.A. Schuler, E.T. Alarid, D.J. Beebe. Biological implications of polydimethylsiloxane-based microfluidic cell culture, Lab on a Chip, 2009
  • 9: 2132-2139.
  • W.J. King, J.Shaikh Mohammed, W.L. Murphy. Modulating growth factor release from hydrogels via a protein conformational change. Soft Matter, 2009
  • 5: 2399-2406.
  • J. Shaikh Mohammed, W.L. Murphy. Bioinspired design of dynamic materials. Advanced Materials, 2009
  • 21:2361-2374.
  • G.A. Hudalla, W.L. Murphy. Using �click� chemistry to prepare substrates to study stem cell adhesion, Langmuir, 2009
  • 25:5737-5746.
  • W.L. Murphy, J.H. Collier. Self-assembling biomaterials, Acta Biomaterialia, 2009
  • 5:803-804.
  • L. Jongpaiboonkit, T. Franklin-Ford, W.L. Murphy. Mineral-coated, biodegradable microspheres for controlled protein binding and release, Advanced Materials, 2009
  • 21:1960-1963.
  • L. Jongpaiboonkit, W.J. King, W.L. Murphy. Screening for 3-D environments that support human mesenchymal stem cell viability using hydrogel arrays, Tissue Engineering A, 2009
  • 15:343-353.
  • J.W. Warrick, W.L. Murphy, D.J. Beebe. Screening the cellular microenvironment: A role for micro-scale culture. IEEE Review of Biomedical Engineering, 2008
  • 1: 75-94.
  • B.J. Peret, W.L. Murphy. Controllable soluble protein concentration gradients in hydrogel networks, Advanced Functional Materials, 2008
  • 18: 3410-3417.
  • S. Choi, W.L. Murphy. Multifunctional mixed SAMs that promote both cell adhesion and non-covalent DNA immobilization, Langmuir, 2008
  • 24:6873-6880.
  • Z. Sui, W.J. King, W.L. Murphy. Protein-based hydrogels with tunable dynamic responses, Advanced Functional Materials, 2008
  • 18:1824-1831.
  • L. Jongpaiboonkit, W.J. King, G.E. Lyons, A. Paguirigan, J. Warrick, D.J. Beebe, W.L. Murphy, Adaptable hydrogel array format for 3-dimensional cell culture, Biomaterials, 2008
  • 29:3346-3356.
  • G. Hudalla, T.S. Eng, W.L. Murphy. An approach to modulate degradation and mesenchymal stem cell behavior in poly(ethylene glycol) networks, Biomacromolecules, 2008
  • 9:842-849.
  • Z. Sui, W.J. King, W.L. Murphy. Dynamic materials based on a protein conformational change. Advanced Materials, 2007
  • 19:3377-3380.



Fall 2015-2016

  • BME 389 - Honors in Research
  • BME 990 - Research and Thesis
  • BME 890 - Pre-dissertation Research
  • BME 790 - Master\'s Research and Thesis
  • BME 699 - Advanced Independent Study
  • BME 399 - Independent Study

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