Shaoqin "Sarah" Gong

Professor

Room: 4166
Wisconsin Institutes for Discovery
330 North Orchard St
Madison, WI 53715

Ph: (608) 316-4311
sgong@engr.wisc.edu

Primary Affiliation:
Biomedical Engineering

Additional Affiliations:
Materials Science Program, Wisconsin Institutes for Discovery


Profile Summary

Prof. Gong's research group focuses on the design, synthesis/fabrication, and characterization of novel materials and devices. Many of our on-going projects are multidisciplinary, bridging engineering with materials science, chemistry, and the life sciences. Some of our on-going efforts include

  1. Multifunctional nanocarriers (e.g., unimolecular micelles, polymer vesicles, functionalized inorganic nanoparticles) for combined delivery of therapeutic and diagnostic agents for targeted cancer therapy and diagnosis, as well as treatment of other diseases (e.g., vascular diseases, and eye diseases)
  2. Multifunctional polymer nanocomposites for various applications including flexible electronics, supercapacitors, actuators, and sensors.
  3. Cellulose nanofibril (CNF)-based aerogels
  4. Biobased plastics and microcellular plastics
  5. Biosensors (especially electrochemical biosensors) made of nanomaterials for the detection of various biomolecules including antigen, DNA, glucose, and urea

Education

  • BS 1991 Economics and Management,Tsinghua University, Beijing, China
  • BS 1991 Materials Science and Engineering, Tsinghua University, Beijing, China
  • MS 1994 Materials Science and Engineering, Tsinghua University, Beijing, China
  • PhD 1999 Materials Science and Engineering, University of Michigan-Ann Arbor

Research Interests

  • Biomaterials (e.g., drug delivery, tissue engineering scaffolds, and biosensors), polymer nanocomposites, devices (e.g., flexible electronics, actuators, sensors, and supercapacitors), biobased plastics, and microcellular plastics.
  • Prof. Gong\'s lab currently has openings for graduate students/postdocs/visiting scholars/exchange students with a strong background in polymer chemistry and materials science. Researchers with expertise in developing novel biomaterials, polymer nanocomposites, and functional devices are strongly encouraged to apply via email.

Awards, Honors and Societies

  • Member of the Editorial Board for the following Journals: Biofabrication, Theranostics, and Journal of Biobased Materials and Bioenergy
  • Associate Editor for Biomaterials
  • Vilas Associate Award, University of Wisconsin-Madison, 2014-2016
  • National Institutes of Health Mentored Quantitative Research Career Development Award 2013-2018
  • National Science Foundation CAREER Award 2007-2012
  • University of Wisconsin-Milwaukee Outstanding Research Award 2007
  • Society for Information Display Award 1998
  • Pre-doctoral Fellowship University of Michigan-Ann Arbor 1997-1998
  • Barbour Fellowship University of Michigan-Ann Arbor, 1996-1997

Publications

Selected publications since 2008

  1. Guo, J., Hong, H., Chen, G., Shi, S., Nayak, T.R., Theuer, C.P., Barnhart, T.E., Cai, W., and Gong S., “Theranostic Unimolecular Micelles Based on Brush-Shaped Amphiphilic Block Copolymers for Tumor-Targeted Drug Delivery and Positron Emission Tomography Imaging” ACS Applied Materials and Interfaces. Invited contribution. Accepted. 2014.
  2. Saraswathy, M., and Gong, S., “Recent Developments in the Co-delivery of siRNA and Anticancer Drug for Cancer Treatment,” Materials Today, Invited review. Accepted, 2014.
  3. Shi, X., Chen, G., Guo, L., Si, Y., Zhu, M., Pilla, S., Liu, B., Gong, S.*, and Kent, C.*, “Periadventitial Application of Rapamycin-Loaded Nanoparticles Produces Sustained Inhibition of Vascular Restenosis,” PLOS ONE. Accepted, 2014. Shi and Chen contributed equally.
  4. Zheng, Q., Cai, Z., Gong, S, “Green Synthesis of Polyvinyl Alcohol (PVA)-Cellulose Nanofibril (CNF) Hybrid Aerogels and Their Use as Superabsorbents,” Journal of Materials Chemistry A, 2(9):3110-3118, 2014.
  5. Gajbhiye, V., Escalante L., Chen, G., Laperle, A., Zheng, Q., Steyer, B., Gong, S.* and Saha. K.*, “Nanoparticle Induced Gene Expression in Human Pluripotent Stem Cell Derivatives,” Nanoscale, 6 (1):521-531, 2014.
  6. Mi, H., Li, Z., Turng, L.S., Sun, Y., Gong, S., \"Silver Nanowire/Thermoplastic Polyurethane Elastomer Nanocomposites: Thermal, Mechanical, and Dielectric Properties,\" Materials and Design, 56:398-404, 2013.
  7. Zheng, Q., Javadi, A., Sabo, R., Cai, Z., and Gong, S., “Polyvinyl Alcohol (PVA)–Cellulose Nanofibril (CNF)–Multiwalled Carbon Nanotube (MWCNT) Hybrid Organic Aerogels with Superior Mechanical Properties,” RSC Advances, 3 (43): 20816-20823, 2013.
  8. Guo, J., Hong, H., Chen, G., Shi, S., Zheng, Q., Zhang Y., Theuer, C.P., Barnhart, T.E., Cai, W., and Gong S., “Image-Guided and Tumor-Targeted Drug Delivery with Radiolabeled Unimolecular Micelles,” Biomaterials, 34(33): 8323-8332, 2013. 
  9. Xu, W., Burke J.F., Pilla, S., Chen, H., Jaskula-Sztul, R., and Gong, S., “Octreotide-Functionalized and Resveratrol-Loaded Unimolecular micelles for Targeted Neuroendocrine Cancer Therapy,” Nanoscale, 5 (20): 9924-9933, 2013.
  10. Saraswathy, M., and Gong, S., “Different Strategies to Overcome Multidrug Resistance,” Biotechnology Advances, 31(8): 1397-1407, 2013.
  11. Javadi, A., Zheng, Q., Payen, F., Javadi, A., Altin, Y., Cai, Z., Sabo R., Gong, S., “Polyvinyl Alcohol-Cellulose Nanofibrillated Fiber-Graphene Oxide Hybrid Organic Aerogels,” ACS Applied Materials & Interfaces, 5(13):5969-75, 2013. 
  12. Xu, W., Siddiqui I., Nihal M., Pilla, S., Rosenthal K., Mukhtar H., and Gong, S, “Aptamer-Conjugated and Doxorubicin-loaded Unimolecular Micelles for Targeted Therapy of Prostate Cancer,” Biomaterials, 34(21):5244-53, 2013
  13. Gajbhiye, V., and Gong, S., “Lectin-Functionalized Nanocarriers for Gene Delivery,” Biotechnology Advances, 31(5):552-562, 2013. (Invited Review).
  14. Xiao, Y., Jaskula-Sztul, R., Javadi, A., Xu, W., Eide, J., Dammalapati, A., Kunnimalaiyaan, M., Chen, H., and Gong, S., “Co-delivery of Doxorubicin and siRNA Using Octreotide-Conjugated Gold Nanorods for Targeted Neuroendocrine Cancer Therapy,” Nanoscale, 4(22):7185-93, 2012.
  15. Xiao, Y., Hao, H., Javadi, A., Englec. J., Xu, W., Yang, Y., Zhang, Y., Barnhart, T., Cai, W., and Gong, S., “Multifunctional Unimolecular Micelles for Cancer-targeted Drug Delivery and Positron Emission Tomography Imaging,” Biomaterials, 33 (11), 3071-3082, 2012. (Leading Opinion Paper).
  16. Xiao, Y., Hong, H., Matson, V., Javadi, A., Xu. W., Yang, Y., Zhang, Y., Engle, J.W., Nickles, R.J., Cai, W., Steeber, D.A., and Gong, S., “Gold Nanorods Conjugated with Doxorubicin and cRGD for Combined Anti-Cancer Drug Delivery and PET Imaging,” Theranostics, 2(8):757-768, 2012.
  17. Javadi, A., Srithep, Y., Clemons, C., Turng, L.S., and Gong, S., “Processing of PHBV-Based Bionanocomposite Foams Using Supercritical Fluids,” Journal of Materials Research, 27 (11), 1506-1517, 2012.
  18. Javadi, A., Xiao, Y., Xu, W., and Gong, S., “Chemically Modified Graphene/P(VDF—TrFE—CFE) Electroactive Polymer Nanocomposites with Superior Electromechanical Performance,” Journal of Materials Chemistry, 22 (3), 830-834, 2012.
  19. Yang, X. Hong, H., Grailer J.J., Rowland, I.J., Javadi, A., Hurley, S.A., Xiao, Y., Yang, Y., Zhang, Y., Nickles, R. J., Cai, W., Steeber, D.A., and Gong, S., “cRGD-Functionalized, DOX-Conjugated, and 64Cu-Labeled Superparamagnetic Iron Oxide Nanoparticles for Targeted Anticancer Drug Delivery and PET/MR Imaging,” Biomaterials, 32 (17), 4151-60, 2011.
  20. Srithep, Y., Javadi, A., Pilla, S., Lee, J., Clemons, C., Gong, S., Turng, L.S., and Jun, P., “Processing and Characterization of Recycled Poly(ethylene terephthalate) (PET) Blends with Chain Extenders (CE), Thermoplastic Elastomer (TPE), and/or Poly(butylene adipate-co-terephthalate) (PBAT),” Polymer Engineering and Science, 51 (6), 1023-1032, 2011.
  21. Yang, M., Javadi, A., and Gong, S., “Sensitive Electrochemical Immunosensor for the Detection of Cancer Biomarker Using Quantum Dot Functionalized Graphene Sheets as Labels,” Sensors and Actuators: B. Chemical, 155 (1), 357-360, 2011.
  22. Javadi, A., Srithep, Y., Pilla, S., Clemons, C., Gong, S., and Turng, L.S., “Microcellular Poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV)-Hyperbranched Polymer-Nanoclay Nanocomposites,” Polymer Science and Engineering, 51 (9), 1815-1826, 2011.
  23. Yang, X., Grailer, J.J., Rowland, I.J., Javadi, A., Hurley, S.A., Vyara, M., Steeber, D.A., and Gong, S., “Multifunctional Stable and pH-Responsive Polymer Vesicles Formed by Heterofunctional Triblock Copolymer for Targeted Anti-Cancer Drug Delivery and Ultrasensitive MR Imaging,” ACS Nano, 4 (11), 6805-6817, 2010.
  24. Yang, X., Grailer, J.J., Rowland, I.J., Javadi, A., Hurley, S.A., Steeber, D.A., and Gong, S., “Multifunctional SPIO/DOX-loaded Wormlike Polymer Vesicles for Cancer Therapy and MR Imaging,” Biomaterials, 31 (34), 9065-73, 2010.
  25. Srithep Y., Javadi, A., Pilla, S., Lee, J., Clemons, C., Gong, S., and Turng, L. S., Jun, P., Processing and Characterization of Recycled Poly(ethylene terephthalate) (PET) Blends with Chain Extenders (CE), Thermoplastic Elastomer (TPE), and/or Poly(butylene adipate-co-terephthalate) (PBAT), Polymer Engineering and Science, 51 (5), 1023-1032, 2010.
  26. Yang, M., Javadi, A., Li, H., and Gong, S., “Ultrasensitive Immunosensor for the Detection of Cancer Biomarker Based on Graphene Sheet,” Biosensors and Bioelectronics, 26 (2), 560-565, 2010.
  27. Pilla, S., Kramschuster, A., Lee, J., Clemons, C., Gong, S., and Turng L.-S., Microcellular Processing of Polylactide-Hyperbranched Polyester-Nanoclay Nanocomposties, Journal of Materials Science, 45(10), 2732-2746, 2010.
  28. Yang, M. and Gong, S., “Immunosensor for the Detection of Cancer Biomarker Based on Percolated Graphene Thin Film,” Chemical Communications, 46, 5796-5798, 2010. (Top five accessed articles of the month).
  29. Yang, X., Grailer, J.J., Pilla, S., Steeber, D.A., Gong, S., and Shuai, X., “Multifunctional Polymeric Vesicles for Targeted Drug Delivery and Imaging,” Biofabrication, 2, 2010, 025004 (8pp).
  30. Javadi, A., Srithep, Y., Pilla, S., Lee, J., Clemons, C., Gong, S., and Turng, L.S., “Processing and Characterization of Microcellular PHBV/PBAT Blends and its Recycled Wood Fiber/Nanoclay Composites,” Composite Part A: Applied Science and Manufacturing, 41 (8), 982-990, 2010.
  31. Javadi, A., Srithep, Y., Pilla, S., Lee, J., Gong, S., and Turng, L. S., “Processing and Characterization of Solid and Microcellular PHBV/Coir Fiber Composites,” Materials Science and Engineering C: Materials for Biological Applications, 40 (5), 749-757, 2010.
  32. Wang, C., Javadi, A., Ghaffari, M., and Gong, S., “A pH-Sensitive Molecularly Imprinted Nanospheres/Hydrogel Composite as a Coating for Implantable Biosensors,” Biomaterials, 31 (8), 4944-4951, 2010.
  33. Yang, X., Grailer, J.J., Pilla, S., Steeber, D.A., and Gong, S., “Tumor-Targeting, pH-Responsive and Stable Unimolecular Micelles as Drug Nanocarriers for Targeted Cancer Therapy,” Bioconjugate Chemistry, 21, 496-504, 2010.
  34. Pilla, S., Kramschuster, A., Lee, J., Clemons, C., Gong, S., and Turng L.S., “Microcellular Processing of Polylactide-Hyperbranched Polyester-Nanoclay Nanocomposties,” Journal of Materials Science, 45 (10), 2732-2746, 2010.
  35. Yang, M., Li, H., Javadi, A., and Gong, S., “Multifunctional Mesoporous Silica Nanoparticles as Labels for the Preparation of Ultrasensitive Electrochemical Immunosensors,” Biomaterials, 31, 3281-3286, 2010.
  36. Javadi, A., Kramschuster A. J., Pilla, S., Lee, J., Gong, S., and Turng, L.S., “Processing and Characterization of Microcellular PHBV/PBAT Blends,” Polymer Engineering and Science, 50 (7), 1440-1448, 2010. Highlighted by the Society of Plastics Engineers online journal in the April 2010 issue.
  37. Prabaharan, M., Grailer, J.J., Pilla, S., Steeber, D.A., and Gong, S., “Gold Nanoparticles with a Monolayer of Doxorubicin-Conjugated Amphiphilic Block Copolymer for Tumor-Targeted Drug Delivery,” Biomaterials, 30, 6065-6075, 2009.
  38. Prabaharan, M., Grailer, J.J., Pilla, S., Steeber, D.A., and Gong, S., “Amphiphilic Multi-Arm-Block Copolymer Conjugated with Doxorubicin via pH-Sensitive Hydrazone Bonds for Tumor-Targeted Drug Delivery,”Biomaterials, 30, 5757-5766, 2009.
  39. Pilla, S., Kim, S. G., Auer G. K., Gong, S., and Park, C., “Microcellular Extrusion Foaming of Poly(lactide)/Poly(butylene adipate-co-terephthalate) Blends,” Materials Science and Engineering C, 30 (2), 255-262, 2010. (Highlighted by Bioplastics Magazine [01/11] Vol. 6, 36-38.)
  40. Aryal, S., Grailer, J.J., Pilla, S., Steeber, D.A., and Gong, S., “Doxorubicin Conjugated Gold Nanoparticles as Water Soluble and pH-Responsive Anticancer Drug Nanocarriers,” Journal of Materials Chemistry, 19 (42), 7879-7884, 2009.
  41. Tiwari, A., Grailer, J.J., Pilla, S., Steeber, D.A., and Gong, S., “Biodegradable Hydrogels Based on Novel Photopolymerizable Guar Gum-Methacrylate Macromonomers for In Situ Fabrication of Tissue Engineering Scaffolds,”Acta Biomaterialia, 5 (9), 3441-3452, 2009.
  42. Li, S., and Gong, S., “A Substrate-Selective Nanoreactor Made of Molecularly Imprinted Polymer Containing Catalytic Silver Nanoparticles,” Advanced Functional Materials, 19 (16), 2601-2606, 2009.
  43. Kohlmeyer, R.R., Javadi, A., Pradhan, B., Pilla, S., Setyowati, K., Chen, J., and Gong, S., “Electrical and Dielectric Properties of Hydroxylated Carbon Nanotube-Elastomer Composites,” Journal of Physical Chemistry, 113 (41), 17626-17629, 2009.
  44. Li, S., and Gong, S., “A Positively Temperature-Responsive, Substrate-Selective Ag Nanoreactor,” Journal of Physical Chemistry B, 113 (52), 16501-16507, 2009.
  45. Prabaharan, M., Grailer, J.J., Pilla, S., Steeber, D.A., and Gong, S., “Folate-Conjugated Amphiphilic Hyperbranched Copolymers Based on Boltorn H40, Poly(L-lactide) and Poly(ethylene glycol) for Tumor-Targeted Drug Delivery,” Biomaterials, 30, 3009-3019, 2009.
  46. Tiwari, A., Aryal, S., Pilla, S., and Gong, S., “An Amperometric Urea Biosensor Based on Covalently Immobilized Urease on An Electrode Made of Hyperbranched Polyester Functionalized Gold Nanoparticles,” Talanta, 78 (4-5), 1401-1407, 2009.
  47. Prabaharan, M., Grailer, J.J., Steeber, D.A., and Gong, S., “Thermo-Sensitive Micelles Based on Folate-Conjugated Poly(N-vinylcaprolactam)-Block-Poly(ethylene glycol) Copolymers for Tumor-Targeted Drug Delivery,”Macromolecule Bioscience, 9 (8), 744-753, 2009.
  48. Aryal, S., Pilla, S., and Gong, S., “Multifunctional Nanomicelles Formed by Amphiphilic Gold-Polycaprolactone-Methoxy Poly(ethylene glycol) (Au-PCL-MPEG) Nanoparticles for Potential Drug Delivery Applications,”Journal of Nanoscience and Nanotechnology, 9 (10), 5701-5708, 2009.
  49. Prabaharan, M., Grailer, J.J., Pilla, S., Steeber, D.A., and Gong, S., “Amphiphilic Multi-Arm-Block Copolymer Based on Hyperbranched Polyester, Poly(L-lactide) and Poly(ethylene glycol) as a Drug Delivery Carrier,”Macromolecular Bioscience, 9 (5), 515-524, 2009.
  50. Li, S., Pilla, S. and Gong, S., “Modulated Molecular Recognition by a Temperature-Sensitive Molecularly Imprinted Polymer,” Journal of Polymer Science Part A: Polymer Chemistry, 47 (9), 2352-2360, 2009.
  51. Pilla, S., Kim, S.G., Auer, G.K., Gong, S., and Park, C.B., “Microcellular Extrusion of Polylactide with Chain-Extender,” Polymer Engineering and Science, 49 (8), 1653-1660, 2009.
  52. Aryal, S., Prabaharan, M., Pilla, S., and Gong, S., “Biodegradable and Biocompatible Multi-Arm Star Amphiphilic Block Copolymer as a Carrier for Hydrophobic Drug Delivery,” International Journal of Biological Macromolecules, 44 (4), 346-352, 2009.
  53. Pilla, S., Kramschuster, A., Yang, L., Gong, S., Chandra, A., and Turng, L.S., “Microcellular Injection Molding of Polylactide with Chain Extender,” Materials Science and Engineering C, 29 (4), 1258-1265, 2009.
  54. Pilla, S., Kramschuster, A., Lee. J., Auer, G. K., Gong, S., and Turng, L. S., “Solid and Microcellular Polylactide-Flax Composites,” Composite Interfaces, 16 (7-9), 869-890 (2009). Invited contribution.
  55. Zhang, C., Subramanian, H., Grailer, J., Tiwari, A., Pilla, S., Steeber, D.A., and Gong, S., “ Fabrication of Biodegradable Poly(trimethylene carbonate) Networkds for Potential Tissue Engineering Scaffold Applications,” Polymers for Advanced Technologies, 20, 742-747, 2009.
  56. Pilla, S., Kramschuster, A., Lee. J., Auer, G.K., Gong, S., and Turng, L. S., “Solid and Microcellular Polylactide-Flax Composites,” Composite Interfaces, 16 (7-9), 869-890, 2009. Invited contribution.
  57. Yang, L., Zhang, C., Pilla, S., and Gong, S., “Polybenzoxazine-Core Shell Rubber-Carbon Nanotube Nanocomposites,” Composites Part A, 39, 1653-1659, 2008.
  58. Pilla S., Yang, L., Gong, S., O’Neill, E., and Rowell, R. M., “Polylactide-Recycled Wood Fiber Composites,” Journal of Applied Polymer Science, 111, 37-47, 2009.
  59. Zhang, C., Liao, L., and Gong, S., “Zinc Lactate Catalyzed Ring-Opening Polymerization of Trimethylene Carbonate Under Microwave Irradiation,” Journal of Applied Polymer Science, 110 (2), 1236-1241, 2008.
  60. Yang, L., Setyowati, K., Li, A., Gong, S., and Chen J., Reversible Infrared Actuation of Carbon Nanotube-Liquid Crystalline Elastomer Nanocomposites, Advanced Materials, 20, 2271-2275, 2008.
  61. Prabaharan, M., and Gong, S., “Novel Thiolated Carboxymethyl Chitosan-g-beta-Cyclodextrin as Mucoadhesive Hydrophobic Drug Delivery Carriers,” Carbohydrate Polymers, 73, 117-125, 2008.
  62. Liao, L., Zhang, C., and Gong, S., “Preparation of Poly(trimethylene carbonate)-Block-Poly(ethylene glycol)-Block-Poly(trimethylene carbonate) Triblock Copolymers Under Microwave Irradiation,” Reactive and Functional Polymers, 68, 751-758, 2008.
  63. Pilla, S., Gong, S., O’Neill, E., Rowell, R. M., and Krzysik A. M., “Polylactide-Pine Wood Flour Composites,” Polymer Science and Engineering, 48 (3), 578-587, 2008.
  64. Prabaharan, M., Grailer, J. J., Steeber, D. A., and Gong, S., “Stimuli-Responsive Chitosan-graft-Poly(N-vinylcaprolactam) as a Promising Material for Controlled Hydrophobic Drug Delivery,” Macromolecular Bioscience, 8(9), 843-51, 2008.
  65. Yang, L., Zhang, C., Pilla, S., and Gong, S., “Polybenzoxazine-Core Shell Rubber-Carbon Nanotube Nanocomposites,” Composites Part A 39, 1653-1659, 2008.

 

 

Links

Courses

Fall 2014-2015

  • BME 890 - Pre-dissertation Research
  • BME 790 - Master\'s Research and Thesis
  • BME 699 - Advanced Independent Study
  • BME 399 - Independent Study
  • Secondary Contact

    Room: 3140
    Engineering Centers Building
    1550 Engineering Drive
    Madison, WI 53706

    Alt Ph: (608) 263-2998

    Profile Summary

    Prof. Gong\'s research group focuses on the design, synthesis/fabrication, and characterization of novel materials and devices. Many of our on-going projects are multidisciplinary, bridging engineering with materials science, chemistry, and the life sciences. Some of our on-going efforts include

    1. Multifunctional nanocarriers (e.g., unimolecular micelles, polymer vesicles, functionalized inorganic nanoparticles) for combined delivery of therapeutic and diagnostic agents for targeted cancer therapy and diagnosis, as well as treatment of other diseases (e.g., vascular diseases, and eye diseases)
    2. Multifunctional polymer nanocomposites for various applications including flexible electronics, supercapacitors, actuators, and sensors.
    3. Cellulose nanofibril (CNF)-based aerogels
    4. Biobased plastics and microcellular plastics
    5. Biosensors (especially electrochemical biosensors) made of nanomaterials for the detection of various biomolecules including antigen, DNA, glucose, and urea

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