Paul J. Campagnola

Professor and Associate Chair of Graduate Advising


Profile Summary

Our lab focuses on studying alterations of the extracellular matrix (ECM) in cancer as well as in connective tissue disorders. To this end, we use Second Harmonic Generation imaging microscopy for imaging structural aspects of tissues, where the approaches will ultimately be implemented as clinical diagnostics. We also use 3D nano/microfabrication approaches to create biomimetic models of the ECM to study signaling pathways associated with cancer and also to provide insight into the design of tissue engineering scaffolds.

Education

  • BA, 1986, Colgate University
  • PhD,1992, Yale University

Research Interests

  • biophotonics
  • tissue imaging
  • breast and ovarian cancer
  • connective tissue disorders
  • nanofabrication
  • cancer cell biology
  • tissue engineering

Publications

  • O. Nadiarnykh and P. J. Campagnola, Retention of polarization signatures in SHG microscopy of scattering tissues through optical clearing, Optics Express, 17, 5794-5806 (2009)
  • X. Chen, M.A. Brewer,C. Zou and P.J. Campagnola, Migration and adhesion of ovarian cancer cells on crosslinked laminin fibers nanofabricated by multiphoton excited photochemistry, Integrative Biology, 1, 469-476 (2009).
  • R. LaComb, O. Nadiarnykh, S. Carey and P.J. Campagnola, Quantitative SHG imaging and modeling of the optical clearing mechanism in striated muscle and tendon J. Biomed Opt.13, 021108 (2008).
  • R. LaComb, O. Nadiarnykh, and P.J. Campagnola, Second Harmonic Generation imaging of osteogenesis imperfecta: experiment and simulation, Biophys. J., 94, 4504-4514 (2008).
  • R. LaComb, O. Nadiarnykh, S. Townsend, and P.J. Campagnola, Phase Matching considerations in Second Harmonic Generation from tissues: Effects on emission directionality, conversion efficiency and observed morphology, Optics Comm, 281, 1823-1832 (2008).
  • L.P. Cunningham, M.P. Veilleux, and P.J. Campagnola, Freeform multiphoton excited microfabrication for biological applications using a rapid prototyping CAD-based approach, Optics Express, 14, 8613-8621 (2006).
  • S. Plotnikov, A.C.Millard, P.J. Campagnola, and W.A. Mohler, Characterization of the myosin-based source for second-harmonic generation from muscle sarcomeres. Biophys J., 90, 693-703, (2006).
  • S. Plotnikov, V. Juneja, A. Isaacson, W.A. Mohler, and P. J. Campagnola, Optical Clearing for Improved Contrast in Second Harmonic Generation Imaging of Skeletal Muscle, Biophys. J.,90, 328-339 (2006)

Courses

Fall 2014-2015

  • PHMCOL-M 619 - Microscopy of Life
  • CHEM 619 - Microscopy of Life
  • BME 990 - Research and Thesis
  • BME 890 - Pre-dissertation Research
  • BME 790 - Master\'s Research and Thesis
  • BME 699 - Advanced Independent Study
  • BME 399 - Independent Study
  • BME 619 - Microscopy of Life
  • RADIOL 619 - Microscopy of Life
  • PHYSICS 619 - Microscopy of Life
  • MEDPHYS 619 - Microscopy of Life
  • Profile Summary

    Our lab focuses on studying alterations of the extracellular matrix (ECM) in cancer as well as in connective tissue disorders. To this end, we use Second Harmonic Generation imaging microscopy for imaging structural aspects of tissues, where the approaches will ultimately be implemented as clinical diagnostics. We also use 3D nano/microfabrication approaches to create biomimetic models of the ECM to study signaling pathways associated with cancer and also to provide insight into the design of tissue engineering scaffolds.


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