Christopher L. Brace

Associate Professor

Room: 1141
Wisconsin Institutes for Medical Research (WIMR)
1111 Highland Ave
Madison, WI 53705

Ph: (608) 262-4151
Fax: (608) 262-4151
clbrace@wisc.edu

Primary Affiliation:
Biomedical Engineering

Additional Affiliations:
Medical Physics, UW-Madison Institute for Clinical and Translational Research, University of Wisconsin Comprehensive Cancer Center, Radiology, DELTA


Profile Summary

Our group is interested in the development of minimally invasive tools for cancer treatment, image-guided therapies, and related fields. Our research is multidisciplinary, with projects including biophysics, electrical and biomedical engineering, medical imaging, numerical simulation, experimental verification, preclinical evaluation and clinical investigation. We are also a translational research group - our projects begin with a clinical focus and many of our developments are now commercial products and/or in widespread clinical use. Please see our Group Website for more information. To inquire about research positions, please email a copy of your CV and provide an outline of proposed research.

Education

  • BS, Electrical Engineering: University of Wisconsin - Milwaukee, 2001.
  • BS, Physics: University of Wisconsin - Milwaukee, 2001.
  • MS, Electrical and Computer Engineering: University of Wisconsin - Madison, 2003.
  • PhD, Electrical and Computer Engineering: University of Wisconsin - Madison, 2005.

Research Interests

  • Bioelectromagnetics
  • Multiphysics modeling
  • Biomedical imaging
  • Image-guided interventions and thermal ablation

Awards, Honors and Societies

  • Active Member, Society of Thermal Medicine
  • Senior Member, IEEE Engineering in Medicine and Biology Society
  • University of Wisconsin Frank Rogers Bacon Fellowship, 2001-2003.
  • Harold A. Peterson Best Dissertation Award, 2005
  • New Investigator Award, Society of Thermal Medicine, 2007.
  • Best Oral Presentation, World Congress on Interventional Oncology, 2008.

Publications

  • Brace CL, van der Weide DW, Lee FT Jr, Laeseke PF and Sampson LA. Analysis and experimental validation of a triaxial antenna for microwave tumor ablation. 2004 IEEE International Microwave Symposium Digest 3:1437-1440, 2004.
  • Brace CL, Laeseke PF, van der Weide DW and Lee FT Jr. Microwave ablation with a triaxial antenna: results in ex vivo bovine liver. IEEE Transactions on Microwave Theory and Techniques 53(1):215-220, 2005.
  • Laeseke PF, Sampson LA, Haemmerich D, Brace CL, Fine JP, Tatum TM, Winter TC III and Lee FT Jr. Multiple-electrode RF ablation: Simultaneous production of separate zones of coagulation in an in vivo porcine liver model. Journal of Vascular Interventional Radiology 16(12):1727-1735, 2005.
  • Laeseke PF, Sampson LA, Brace CL, Winter TC III, Fine JP and Lee FT Jr. Unintended thermal injuries from radiofrequency ablation: Protection with 5% dextrose in water. American Journal of Roentgenology 186:S249-S254, 2006.
  • Laeseke PF, Sampson LA, Haemmerich D, Brace CL, Fine JP, Tatum TM, Winter TC III and Lee FT Jr. Multiple-electrode radiofrequency ablation creates confluent areas of necrosis: Results in in vivo porcine liver. Radiology 241:116-124, 2006.
  • Brace CL, Laeseke PF, Prasad V and Lee FT Jr. Electrical isolation of organs during radiofrequency ablation: 5% dextrose in water provides better protection than saline. IEEE Engineering in Medicine and Biology 1:5021-5024, 2006.
  • Brace CL, Microwave ablation technology avoids problems that plague RFA, offers promise for new applications. DiagnosticImaging.com feature, Mar 13, 2006.
  • Brace CL, Laeseke PF, Sampson LA, Frey TM, van der Weide DW and Lee FT Jr. Microwave ablation with a single small-gauge triaxial antenna: In vivo porcine liver model. Radiology 242:435-440, 2007.
  • Brace CL, Laeseke PF, Sampson LA, Frey TM, van der Weide DW and Lee FT Jr. Microwave ablation with multiple simultaneously powered small-gauge triaxial antennas: Results from an in vivo swine liver model. Radiology 244:151-156, 2007.
  • Laeseke PF, Frey TM, Brace CL, Sampson LS, Winter TW III and Lee FT Jr. Multiple-electrode RF ablation of hepatic malignancies: Initial clinical experience. American Journal of Roentgenology 188:1485-1494, 2007.
  • Brace CL, Laeseke PF, Frey TM, Sampson LS and Lee FT Jr. Radiofrequency ablation with a high-power generator: Device efficacy in an in vivo porcine liver model. International Journal of Hyperthermia 23(4):387-294, 2007.
  • Laeseke PF, Sampson LS, Frey TM, Mukherjee R, Winter TC III, Lee FT Jr and Brace CL. Multiple-electrode radiofrequency ablation: comparison with a conventional cluster electrode in an in vivo porcine kidney model. Journal of Vascular and Interventional Radiology 18:1005-1010, 2007.
  • Durick N, Laeseke PF, Broderick LS, Warner TM, Frey TM, Sampson LA, Van der Weide DW, Lee FT Jr, and Brace CL. Microwave ablation with triaxial antennas tuned for lung: Results in an in vivo porcine model. Radiology 247:80-87, 2008.
  • Brace CL. Temperature-dependent dielectric properties of liver tissue measured during thermal ablation: Toward an improved numerical model. IEEE Engineering in Medicine and Biology 1:230-233, 2008.
  • Hinshaw JL, Lee FT Jr, Sampson LA, and Brace CL. Does selective intubation increase ablation zone size during pulmonary cryoablation? Journal of Vascular and Interventional Radiology 19:1497-1501, 2008.
  • Brace CL, Sampson LA, Hinshaw JL, Sandhu N, and Lee FT Jr. Radiofrequency ablation: Simultaneous application of multiple electrodes via switching creates larger, more confluent ablations than sequential application. Journal of Vascular and Interventional Radiology 20:118-124, 2009.
  • Jiang JJ, Varghese T, Brace CL, Madsen EL, Hall TJ, Bharat S, Hobson MA, Zagzebski JA, Lee FT Jr. Young\'s modulus reconstruction for radio-frequency ablation electrode-induced displacement fields: A feasibility study. IEEE Trans Medical Imaging 28(8):1325-1334, 2009.
  • Brace CL. Microwave and radiofrequency ablation of the liver, lung, kidney and bone: What are the differences? Current Problems in Diagnostic Radiology 38:135-143, 2009.
  • Brace CL. Microwave ablation technology: What every user should know. Current Problems in Diagnostic Radiology 38:61-68, 2009.
  • Brace CL, Hinshaw JL, Laeseke PF, Sampson LA, and Lee FT Jr. Pulmonary thermal ablation: Comparing radiofrequency and microwave devices using gross pathology and CT imaging. Radiology 251:705-711, 2009.
  • Wang P, Brace CL, Converse M, Webster JW.Tumor boundary estimation through time domain peaks monitoring: Numerical predictions and experimental results in tissue mimicking phantoms. IEEE Transaction on Biomedical Engineering Epub ahead of print, Jun 26 2009.
  • Laeseke PF, Sampson LA, Lee FT Jr and Brace CL. Microwave ablation versus radiofrequency ablation in the kidney: High-power triaxial antennas create larger ablation zones than similarly sized internally cooled electrodes. Journal of Vascular and Interventional Radiology Epub ahead of print, Jul 17 2009.
  • Brace CL, Mistretta CA, Hinshaw JL, Lee FT Jr. Periodic contrast-enhanced computed tomography for ablation treatment monitoring. IEEE Engineering in Medicine and Biology, 1:4299-4302, 2009.
  • Laeseke PF, Sampson LA, Lee FT Jr and Brace CL. Multiple-antenna microwave ablation: Spatially distributing power improves thermal profiles and reduces invasiveness. Journal of Interventional Oncology 2(2):65-72, 2009.
  • Hinshaw JL, Durick NA, Leung W, Lee FT Jr, Warner TF, Sampson LA, and Brace CL. Radiology-pathology correlation for pulmonary cryoablation in a porcine model. Journal of Interventional Oncology 2(2):73-79, 2009.
  • Rubert N, Bharat S, DeWall RJ, Andreano A, Brace CL, Jiang J, Sampson LA, Varghese T. Electrode displacement strain imaging of thermally-ablated liver tissue in an in vivo animal model. Medical Physics 37(3):1075-1082, 2010.
  • Andreano A, Huang Y, Meloni MF, Lee FT Jr, Brace CL. Microwaves create larger ablations than radiofrequency when controlled for power in ex vivo tissue. Medical Physics 37(6):2967-2973, 2010.
  • Brace CL, Diaz TA, Hinshaw JL, Lee, FT Jr. Tissue contraction caused by radiofrequency and microwave ablation: A laboratory study in liver and lung. Journal of Vascular and Interventional Radiology 21(8):1280-1286, 2010.
  • Hinshaw JL, Sampson LA, Lee FT Jr, Brace CL. Optimizing the protocol for pulmonary cryoablation:A comparison of a dual and triple freeze protocol. Cardiovascular and Interventional Radiology 33:1180-5, 2010.
  • Jiang J, Brace CL, Andreano A, DeWall RJ, Rubert N, Fisher T, Varghese T, Lee FT Jr, Hall TJ.Ultrasound-based elastic modulus imaging for visualizing thermal ablation zones in a porcine model. Physics in Medicine and Biology 55(8):2281-2306, 2010.
  • Lubner MG, Brace CL, Hinshaw JL, Lee FT Jr. Microwave tumor ablation: Mechanism of action, clinical results and devices. Journal of Vascular and Interventional Radiology 21(8 suppl):S192-203, 2010.
  • Brace CL. Microwave tissue ablation: Biophysics, technology and applications. Critical Reviews in Biomedical Engineering 38(1):65-78, 2010.
  • Hinshaw JL, Durick NA, Leung W, Lee FT Jr, Sampson LA, Brace CL. Temperature isotherms during pulmonary cryoablation and their correlation with the zone of ablation. Journal of Vascular and Interventional Radiology 21(9):1424-1428, 2010.
  • Ahmed M, Brace CL, Lee FT Jr, Goldberg SN. Principles of and advances in percutaneous ablation. Radiology 258(2):351-369, 2011.
  • View PubMed listings

Courses

Fall 2014-2015

  • BME 890 - Pre-dissertation Research
  • BME 790 - Master\'s Research and Thesis
  • BME 699 - Advanced Independent Study
  • BME 399 - Independent Study
  • BME 389 - Honors in Research
  • BME 535 - Introduction to Energy-Tissue Interactions
  • MEDPHYS 535 - Introduction to Energy-Tissue Interactions
  • Profile Summary

    Our group is interested in the development of minimally invasive tools for cancer treatment, image-guided therapies, and related fields. Our research is multidisciplinary, with projects including biophysics, electrical and biomedical engineering, medical imaging, numerical simulation, experimental verification, preclinical evaluation and clinical investigation. We are also a translational research group - our projects begin with a clinical focus and many of our developments are now commercial products and/or in widespread clinical use. Please see our Group Website for more information. To inquire about research positions, please email a copy of your CV and provide an outline of proposed research.


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