David Beebe

John D. MacArthur Professor & Claude Bernard Professor

Room: 6009
Wisconsin Institutes for Medical Research
1111 Highland Drive
Madison, WI 53705

Ph: (608) 262-2260
Fax: (608) 265-6905
djbeebe@wisc.edu

Primary Affiliation:
Biomedical Engineering

Additional Affiliations:
Materials Science Program, Biotechnology Training Program, Cancer Biology Program, Chemistry-Biology Interface Training Program, Computation and Informatics in Biology and Medicine, Genome Sciences Training Program, Laboratory for Optical and Computational Instrumentation, Materials Science Program, Molecular and Cellular Pharmacology, UW Carbone Cancer Center, Wisconsin Institutes for Medical Research


Profile Summary

Our goal is a holistic approach to understanding cell behavior that integrates in vitro cellular scale engineering to recapitulate important in vivo microenvironmental characteristics in ways that provide biological insights, aid in diagnosis/treatment and enhance discovery. While our particular interests center around cancer biology, our work has broad potential application across cell biology.

Education

  • Ph.D. 1994, University of Wisconsin - Madison

Research Interests

  • Microfluidics
  • Cell & Cancer biology

Awards, Honors and Societies

  • IEEE EMBS Early Career Achievement Award, 2001
  • Romnes Award, UW-Madison, 2003
  • Fellow, Royal Society of Chemistry, 2005
  • Lab on a Chip, Royal Society of Chemistry and Corning, Pioneers of Miniaturization Prize, 2006
  • Fellow, American Institute for Medical and Biological Engineering (AIMBE), 2007
  • Founding Scientific Editor, Integrative Biology, Royal Society of Chemistry, 2009

Publications

  • Beebe, D. J., J. S. Moore, J. M. Bauer, Q. Yu, R. H. Liu, C. Devadoss, B-H. Jo, \"Functional structures for autonomous flow control inside micro fluidic channels,\" Nature, vol. 404, pp. 588-590, 2000.
  • Beebe, D. J., J. Moore, Q. Liu, R. H. Liu, M. L. Kraft, B-H. Jo and C. Devadoss, \"Microfluidic Tectonics: A comprehensive construction platform for microfluidic systems,\" Proceedings of the National Academy of Science, vol. 97, No. 25, pp. 13488-13493, 2000.
  • Liu, R. H., K. V. Sharp, M. G. Olsen, M. Stremler, J. G. Santiago, R. J. Adrian, H. Aref, D. J. Beebe, \"A Passive three-dimensional \'C-shape\' helical micromixer,\" Journal of Microelectromechanical Systems, vol. 9, No. 2, pp. 190-198, 2000.
  • Zhao, B., J. S. Moore and D. J. Beebe, \"Surface-directed liquid flow inside microchannels,\" Science, vol. 291, pp. 1023-1026, 2001.
  • Walker, G. M. and D. J. Beebe, \"A passive pumping method for microfluidic devices,\" Lab on a Chip, vol. 2, pp. 131-134, 2002.
  • Walker, G. M., H. Zeringue and D. J. Beebe, \"Microenvironment design considerations for cellular scale studies,\" Lab. Chip., vol. 4, pp. 91-97, 2004.
  • Atencia, J. and D. J. Beebe, \"Controlled microfluidic interfaces,\" Nature, vol. 437, pp. 648-655, 2005.
  • Dong, L., A. K. Agarwal, D. J. Beebe and H. Jiang,\"Smart liquid microlenses,\" Vol. 442, pp. 551-554, Nature, 2006.
  • Yu, H., C. M. Alexander and D. J. Beebe, \"Understanding microchannel culture: parameters involved in soluble factor signaling,\"Lab on a Chip, Vol. 7, pp. 726-730, 2007.
  • Paguirigan A, and D. J. Beebe, \"Microfluidics, meet cell biology:bridging the gap by validation and application of microscale techniques for cell biological assays,\" Bioessays, Vol. 30, pp. 811-821, 2008.
  • Domenech. M., H. Yu, J. Warrick, N. M. Badders, I. Meyvantsson, C. M. Alexander, and D. J. Beebe, \"Cellular observations enabled by microculture: paracrine signaling and population demographics,\" Integrative Biology, Vol. 1, pp. 267 - 274, 2009.
  • Young, E. W. K and D. J. Beebe, \"Fundamentals of microfluidic cell culture in controlled microenvironments,\" Chemical Society Reviews, Vol. 39, pp. 136-148, 2010.

Courses

Fall 2014-2015

  • ME 990 - Dissertator Research and Thesis

  • ME 890 - PhD Research and Thesis
  • INTEREGR 301 - Engineering and Biology: Technological Symbiosis
  • BME 990 - Research and Thesis
  • BME 890 - Pre-dissertation Research
  • BME 790 - Master\'s Research and Thesis
  • BME 699 - Advanced Independent Study
  • BME 399 - Independent Study
  • BME 389 - Honors in Research
  • Profile Summary

    Our goal is a holistic approach to understanding cell behavior that integrates in vitro cellular scale engineering to recapitulate important in vivo microenvironmental characteristics in ways that provide biological insights, aid in diagnosis/treatment and enhance discovery. While our particular interests center around cancer biology, our work has broad potential application across cell biology.


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