Brian founded the MOXI research group when he came to serve as Chair of the Department of Medical Physics in 2022. His research program focuses on development of unique optical tools and techniques for advanced surgery and radiation therapy guidance, photodynamic therapy, molecular imaging, and theranostics. He has raised $42 Million in NIH funding, translated dozens of imaging systems into human trials, and published >475 scientific peer-reviewed articles. He is Editor in Chief of the Journal of Biomedical Optics, and elected Fellow of AIMBE, Optica, SPIE, AAPM & the National Academy of Inventors.